ABSTRACT Using the Lyman α (Lyα) Mass Association Scheme, we make theoretical predictions for the three-dimensional three-point correlation function (3PCF) of the Lyα forest at redshift z = 2.3. We bootstrap results from the (100 h−1 Mpc)3 Horizon hydrodynamic simulation to a (1 h−1 Gpc)3N-body simulation, considering both a uniform ultraviolet background (UVB) and a fluctuating UVB sourced by quasars with a comoving nq ≈ 10−5h3 Mpc−3 placed either in massive haloes or randomly. On scales of 10–30 h−1 Mpc, the flux 3PCF displays hierarchical scaling with the square of the two-point correlation function (2PCF), but with an unusual value of Q ≡ ζ123/(ξ12ξ13 + ξ12ξ23 + ξ13ξ23) ≈ −4.5 that reflects the low bias of the Lyα forest and the anticorrelation between mass density and transmitted flux. For halo-based quasars and an ionizing photon mean free path of λ = 300 h−1 Mpc comoving, UVB fluctuations moderately depress the 2PCF and 3PCF, with cancelling effects on Q. For λ = 100 or 50 h−1 Mpc, UVB fluctuations substantially boost the 2PCF and 3PCF on large scales, shifting the hierarchical ratio to Q ≈ −3. We scale our simulation results to derive rough estimate of the detectability of the 3PCF in current and future observational data sets for the redshift range z = 2.1–2.6. At r = 10 and 20 h−1 Mpc, we predict a signal-to-noise ratio (SNR) of ∼9 and ∼7, respectively, for both Baryon Oscillation Spectroscopic Survey (BOSS) and extended BOSS (eBOSS), and ∼37 and ∼25 for Dark Energy Spectroscopic Instrument (DESI). At r = 40 h−1 Mpc the predicted SNR is lower by a factor of ∼3–5. Measuring the flux 3PCF would provide a novel test of the conventional paradigm of the Lyα forest and help separate the contributions of UVB fluctuations and density fluctuations to Lyα forest clustering, thereby solidifying its foundation as a tool of precision cosmology.