Display omitted •A new “information system” is proposed for mineral exploration targeting.•The system is called “exploration information system” (EIS).•EIS uses “mineral system” concepts in conjunction with GIS.•Ore-forming processes are classified into pre-, syn-, and post-mineralization parts.•EIS aims to automated translation of ore-forming processes into spatial proxies. The advent of modern data collection and storage technologies has brought about a huge increase in data volumes with both traditional and machine learning tools struggling to effectively handle, manage and analyse the very large data quantities that are now available. The mineral exploration industry is by no means immune to this big data issue. Exploration decision-making has become much more complex in the wake of big data, in particular with respect to questions about how to best manage and use the data to obtain information, generate knowledge and gain insight. One of the ways in which the mineral exploration industry works with big data is by using a geographic information system (GIS). For example, GIS platforms are often used for integration, interrogation and interpretation of diverse geoscience and mineral exploration data with the goal of refining and prioritising known and identifying new targets. Here we (i) briefly discuss the importance of carefully translating conceptual ore deposit models into effective exploration targeting maps, (ii) propose and describe what we term exploration information systems (EIS): a new idea for an information system designed to better integrate the conceptual mineral deposit model (i.e., the critical and constituent processes of the targeted mineral system) with data available to support exploration targeting, and (iii) discuss how best to categorise mineral systems in an EIS as scale-dependent subsystems to form mineral deposits. Our vision for the future use of EIS in exploration targeting is one whereby the mappable ingredients of a targeted mineral system are translated and combined into a set of weighted evidence (or proxy) maps automatically, resulting in an auto-generated mineral prospectivity map and a series of ranked exploration targets. We do not envisage the EIS replacing human input and ingenuity; rather we envisage the EIS as an additional tool in the exploration toolbox and as an intelligence amplifying system in which humans are making use of machines to achieve the best possible results.