Since the emergence of more amd more HIV infected individuals and increasing trend of community acquired Methicillin resistance Staphylococcus aureus, it is important to know the prevalence of MRSA in a community. Nasal and axillary swabs were taken from a community centre for seropositive children and processed for isolation of MRSA by CLSI 2015 guidelines. Among the 90 Staphyloccus aureus, 33(34.8%) were resistant to methicillin and to ceftriaxone 22%, ciprofloxacin 26%, clindamycin 17%, co-trimoxazole 6.2%, erythromycin 29.7%, tetracycline 15.4% and chloramphenicol 8.4%. From the above study it can be concluded that community acquired MRSA is increasing among the seropositive patients and they should be treated with mupirocin and chlorhexedine which will be helpful in decreasing the morbidity and mortality associated with it.