Presented in this volume are the Invited Lectures and the Contributed Papers of the Tenth International Workshop on Decoherence, Information, Complexity and Entropy – DICE 2022 “Quantum riddles and spacetime oddities” held at Castello Pasquini, Castiglioncello (Tuscany), September 19-23, 2022 . These proceedings document the lively exchange of ideas during the conference for the interested public and the scientific community alike. – For further details on all aspects of the meeting, cf. the website at http://osiris.df.unipi.it/~elze/DICE2022.html. Our intention in this series of conferences has always been to unite leading researchers, advanced students, and renowned scholars from various areas, in order to stimulate new ideas and their exchange across the borders of specialization. The meetings in this series have successfully grown from DICE 2002, 1 followed by DICE 2004, 2 DICE 2006, 3 DICE 2008, 4 DICE 2010, 5 DICE 2012, 6 DICE 2014, 7 DICE 2016, 8 and DICE 2018. 9 About 80 participants from all over the world attended DICE 2022, with which the conference series resumed for the first time following the covid-19 pandemic.