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Vlasenko, A.E.; Velansky, P.V.; Chernyshev, A.V.; Kuznetsov, V.G.; Magarlamov, T. Yu
Toxicon (Oxford), 12/2018, Letnik: 156Journal Article
For the first time search for tetrodotoxin (TTX) and its analogues in the extracts of nemerteans using HPLC-MS/MS was performed. TTX analogues were detected in two nemertean species in addition to TTX: 7 analogues were detected in the extract of Cephalothrix simula, 3 analogues - in the extract 11-norTTX of Kulikovia manchenkoi. Presence of 5-deoxyTTX, 11-deoxyTTX, 5,6,11-trideoxyTTX and −6(R)-ol in nemerteans was shown for the first time. •TTX and its analogues were first detected in ribbon worms via HPLC-MS/MS.•Four analogues of TTX were revealed in nemertean species for the first time.•5-deoxyTTX (K. manchenkoi) and 5,6,11-trideoxyTTX (C. simula) are dominant toxins.
