Abstract We present the first high-resolution abundance analysis of the globular cluster VVV CL001, which resides in a region dominated by high interstellar reddening toward the Galactic bulge. Using H -band spectra acquired by the Apache Point Observatory Galactic Evolution Experiment, we identified two potential members of the cluster, and estimated from their Fe i lines that the cluster has an average metallicity of Fe/H = −2.45 with an uncertainty due to systematics of 0.24 dex. We find that the light-(N), α -(O, Mg, Si), and Odd- Z (Al) elemental abundances of the stars in VVV CL001 follow the same trend as other Galactic metal-poor globular clusters. This makes VVV CL001 possibly the most metal-poor globular cluster identified so far within the Sun’s galactocentric distance and likely one of the most metal-deficient clusters in the Galaxy after ESO280-SC06. Applying statistical isochrone fitting, we derive self-consistent age, distance, and reddening values, yielding an estimated age of 11.9 − 4.05 + 3.12 Gyr at a distance of 8.22 − 1.93 + 1.84 kpc, revealing that VVV CL001 is also an old GC in the inner Galaxy. The Galactic orbit of VVV CL001 indicates that this cluster lies on a halo-like orbit that appears to be highly eccentric. Both chemistry and dynamics support the hypothesis that VVV CL001 could be an ancient fossil relic left behind by a massive merger event during the early evolution of the Galaxy, likely associated with either the Sequoia or the Gaia–Enceladus–Sausage structures.