Palladium‐catalyzed cascade cyclization received much attention in organic synthesis due to its efficiency and rapid transformation of simple starting materials into complex molecular skeletons. Celebrating the 10th year of the prestigious Nobel prize for palladium chemistry, we witness it still proceeds strong over other transition metals for its versatility. Cascade reactions in contemporary organic synthesis reduced cost and time through careful design. It has emerged as the first choice, a powerful tool for multiple bond formations in one step with a wide range of functional group tolerance due to the deep understanding of various pathways. A variety of compounds with biological relevance with complex molecular scaffolds have been achieved using these cascade coupling reactions. This review outlines Pd‐catalyzed cascade reactions from the post‐Nobel era. Nevertheless, more discoveries and endless possibilities for new transformations are underway. Celebrating the tenth year of the prestigious Nobel prize in 2010 for palladium chemistry; still, palladium stands strong over other transition metals for its versatility. Cascade reactions in contemporary organic synthesis reduced cost and time through careful design. This review outlines Pd‐catalyzed cascade reactions in organic synthesis from the post‐Nobel era.