Yarrow (Achillea millefolium L.) is a herbaceous plant from family Astereaceae, that has a long history of use in traditional medicine. The genus name Achillea is derived from greek mythology. Namely, the famous military leader, Achilles, carried it with his army to treat battle wounds. The subject of this study was the research of ethnopharmacological application of yarrow in the Pirot county. The study was conducted in the form of surveys among the population in four municipalities: Pirot, Babušnica, Bela Palanka and Dimitrovgrad. It was noticed that yarrow is one of ten best known medicinal plant species in the Pirot county. It is usualy used in the form of herbal tea against stomach diseases, especially for stomach, for appetite, improving immunity, and fresh herb in the form of compress for wounds.