This Review aims to integrate the most recent and pertinent data available on the (bio)degradability and toxicity of ionic liquids for global and critical analysis and on the conscious use of these compounds on a large scale thereafter. The integrated data will enable focus on the recognition of toxicophores and on the way the community has been dealing with them, with the aim to obtain greener and safer ionic liquids. Also, an update of the most recent biotic and abiotic methods developed to overcome some of these challenging issues will be presented. The review structure aims to present a potential sequence of events that can occur upon discharging ionic liquids into the environment and the potential long‐term consequences. Breaking it down: This Review aims to integrate the most recent and pertinent data available on the biodegradability and ecotoxicity of ionic liquids. A critical analysis of new developed methods to enhance the degradability of ionic liquids and their removal from wastewater is also presented.