The schematic diagram of sensor construction Display omitted We described a novel electrochemical sensor for amoxicillin (AMOX), which was constructed by multiwalled carbon nanotubes@molecularly imprinted polymer (MWCNTs@MIP), single walled carbon nanotube (SWCNT) and dendritic Pt-Pd nanoparticle (NP). Firstly, ionic liquid (IL, i.e. 3-propyl-1-vinylimidazolium bromide) was grafted onto MWCNTs surface to form MWCNTs@IL by using an ionic exchange strategy. Then, the resulting MWCNTs@IL was used as monomer to synthesize MWCNTs@MIP. Meanwhile, dendritic Pt-Pd bimetallic NP was prepared by using hexadecylpyridinium chloride and hexamethylenetriamine as synergetic structure-directing agents, and then it was dispersed into SWCNT suspension. After that, the hybrid suspension was dropped on a glassy carbon electrode, followed by coating with MWCNTs@MIP. Under the optimal conditions, the obtained sensor presented linear response to AMOX in the ranges of 1.0×10−9∼1.0×10−6molL−1 and 1.0×10−6∼6.0×10−6, respectively, and its detection limit was 8.9×10−10molL−1. This sensor was used to detect AMOX in real samples with satisfactory results.