Inspired by the highly versatile natural motors, artificial micro‐/nanomotors that can convert surrounding energies into mechanical motion and accomplish multiple tasks are devised. In the past few years, micro‐/nanomotors have demonstrated significant potential in biomedicine. However, the practical biomedical applications of these small‐scale devices are still at an infant stage. For successful bench‐to‐bed translation, biocompatibility of micro‐/nanomotor systems is the central issue to be considered. Herein, the recent progress in micro‐/nanomotors in biocompatibility is reviewed, with a special focus on their biomedical applications. Through close collaboration between researches in the nanoengineering, material chemistry, and biomedical fields, it is expected that a promising real‐world application platform based on micro‐/nanomotors will emerge in the near future. The biocompatibility of artificial micro‐/nanomotors is essential for real‐world biomedical applications. Recent progress about biocompatible micro‐/nanomotor systems that are based on biocompatible framework materials, chemical fuels (e.g., water, glucose, urea, and acid), external fields (e.g., magnetic field, light, and ultrasound) and biohybrid, is discussed here.