E-viri
Recenzirano
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Xie, Xianli; Sun, TianCi; Xue, Jingzhe; Miao, Zhaohua; Yan, Xu; Fang, WeiWei; Li, Qing; Tang, Rupei; Lu, Yang; Tang, Longxiang; Zha, Zhengbao; He, Tao
Advanced functional materials, 04/2020, Letnik: 30, Številka: 17Journal Article
Antibacterial efficiency can be effectively improved by applying targeting antibacterial materials and strategies. Herein, the successful synthesis of uniform pH‐responsive Ag nanoparticle clusters (AgNCs) is demonstrated, which can collapse and reassemble into nonuniform Ag NPs upon exposure to the acidic microenvironment of bacterial infections. This pH triggered reassembly contributes greatly to the improved antibacterial activities of AgNCs against both methicillin‐resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli). The minimum inhibitory concentration and minimum bactericidal concentration against MRSA are as low as 4 and 32 µg mL−1 (which are 8 and 32 µg mL−1 for E. coli), respectively. In vivo skin wound healing experiments confirm AgNCs can serve as an effective wound dressing to accelerate the healing of MRSA infection. The development of responsive AgNCs offers new materials and strategies in targeting antibacterial applications. The designed Ag nanoparticles clusters can undergo a collapse and reassembly process upon exposure to the acidic microenvironment of bacterial infections, which results in the highly efficient targeting antibacterial ability.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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