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Neuwirth, Aleš; Dobeš, Jan; Oujezdská, Jana; Ballek, Ondřej; Benešová, Martina; Šumník, Zdeněk; Včeláková, Jana; Koloušková, Stanislava; Obermannová, Barbora; Kolář, Michal; Štechová, Kateřina; Filipp, Dominik
Cellular immunology, 2012, 2012-00-00, 20120101, Letnik: 273, Številka: 2Journal Article
► Thirty percent of patients with T1D exhibit increased levels of m-α-defensin mRNAs in their capillary blood. ► Increased m-α-defensin levels were observed in capillary but not in venous blood samples. ► CD15dull/CD14weak eosinophil population was identified as the cellular source of m-α-defensins. ► Eosinophils from all T1D patients tested displayed augmented m-α-defensin expression. ► Eosinophils could contribute to the magnitude of inflammation and β-cell destruction. Type 1 diabetes (T1D) is an autoimmune disease caused by T-cell mediated destruction of pancreatic beta cells. Recently, small cationic α-defensin molecules have been implicated in the pathogenesis of certain inflammatory and autoimmune diseases. The purpose of this study was to assess the α-defensin expression in patients with T1D and elucidate the cellular source of their production. Our results show that 30% of patients exhibit increased levels of α-defensin mRNAs in their capillary blood. Quantitative RT-PCR performed on FACS-sorted granulocytes identified CD15dull/CD14weak population as the cellular source of α-defensins. Surprisingly, this granulocyte subpopulation displayed augmentation of α-defensin expression in all T1D patients tested. The determination of cell surface markers, expression of cell-specific genes and confocal microscopy identified CD15dull/CD14weak cells as eosinophils. The presence of transcriptionally active eosinophils in diabetic patients suggests that eosinophils could be a part of an intricate innate immune cellular network involved in the development of diabetes.
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