Extrusion of pastes from squeezable tubes is a ubiquitous but complex process, and it is not well studied. A common example is toothpaste, which needs to be easily extrudable from its tube, but it is not always the case due to the complex rheology of the paste. This may be particularly problematic if the base liquid in the formula is anhydrous leading to the paste hardening at temperatures close to ambient. In this work, we use various testing techniques to study the squeezability of the tubes containing hydrous and anhydrous paste formulations. We show that mechanical testing imitating human hand operation adequately predicts the actual sensorial panel data while also correlating with simple viscosity measurements. Furthermore, for anhydrous pastes sensitive to cooling their effective hardening temperature may be predicted by thermal analysis of their base liquids. Overall, it is expected that the results and the methodologies presented in this work will be of good guidance for product/packaging developers. Display omitted •Rheology and cooling effect on paste extrusion were investigated using texture analysis.•Paste extrusion from squeezable tubes correlates with the measured viscosity.•The freezing/hardening point of anhydrous bases and their pastes was also investigated by rheological and thermal analysis.•Anhydrous bases and their pastes showed similar freezing/hardening behavior.•Studying the freezing point of the base suffices to determine the hardening point of its paste.