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Wang, Zhenming; Zhao, Jin; Tang, Wanze; Hu, Liqiu; Chen, Xin; Su, Yiping; Zou, Chang; Wang, Jianhong; Lu, William W.; Zhen, Wanxin; Zhang, Ronghua; Yang, Dazhi; Peng, Songlin
Small (Weinheim an der Bergstrasse, Germany), 10/2019, Letnik: 15, Številka: 41Journal Article
Tissue‐engineered hydrogels have received extensive attention as their mechanical properties, chemical compositions, and biological signals can be dynamically modified for mimicking extracellular matrices (ECM). Herein, the synthesis of novel double network (DN) hydrogels with tunable mechanical properties using combinatorial screening methods is reported. Furthermore, nanoengineered (NE) hydrogels are constructed by addition of ultrathin 2D black phosphorus (BP) nanosheets to the DN hydrogels with multiple functions for mimicking the ECM microenvironment to induce tissue regeneration. Notably, it is found that the BP nanosheets exhibit intrinsic properties for induced CaP crystal particle formation and therefore improve the mineralization ability of NE hydrogels. Finally, in vitro and in vivo data demonstrate that the BP nanosheets, mineralized CaP crystal nanoparticles, and excellent mechanical properties provide a favorable ECM microenvironment to mediate greater osteogenic cell differentiation and bone regeneration. Consequently, the combination of bioactive chemical materials and excellent mechanical stimuli of NE hydrogels inspire novel engineering strategies for bone‐tissue regeneration. Black phosphorus (BP) nanosheets–based hydrogels show excellent mechanical properties, favorable mineralization, and high bioactivity. The ultra‐high strength hydrogels are made of covalent bonds combined with a high density of polymer entanglements and hydrogen bonds. Notably, the BP nanosheets exhibit intrinsic properties for induced calcium phosphate particle formation and therefore improve the mineralization of the hydrogels.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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