Yih-Shou Hsieh 1, 2 and Shun-Fa Yang 1,3 and Gautam Sethi 4 and Dan-Ning Hu 5 1, Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan 2, Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan 3, Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan 4, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 119077, Singapore 5, Tissue Culture Center, New York Eye and Ear Infirmary, New York Medical College, New York, NY 10009, USA Received 18 December 2014; Accepted 18 December 2014; 26 March 2015 This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.