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Bock, Nathalie; Woodruff, Maria A.; Steck, Roland; Hutmacher, Dietmar W.; Farrugia, Brooke L.; Dargaville, Tim R.
Macromolecular bioscience, 02/2014, Letnik: 14, Številka: 2Journal Article
A novel strategy is reported to produce biodegradable microfiber‐scaffolds layered with high densities of microparticles encapsulating a model protein. Direct electrospraying on highly porous melt electrospun scaffolds provides a reproducible scaffold coating throughout the entire architecture. The burst release of protein is significantly reduced due to the immobilization of microparticles on the surface of the scaffold and release mechanisms are dependent on protein‐polymer interactions. The composite scaffolds have a positive biological effect in contact with precursor osteoblast cells up to 18 days in culture. The scaffold design achieved with the techniques presented here endorses these new composite scaffolds as promising templates for growth factor delivery. A novel platform for protein delivery is established here. Highly porous microfiber constructs are homogeneously coated by direct electrospraying of biodegradable microparticles loaded with proteins. Control over porosity, scaffold coating, and characteristics of particles are obtained with the processing parameters for tailored protein delivery required in tissue engineering.
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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