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Gerlach, Carmen; Rohr, Jan C.; Perié, Leïla; van Rooij, Nienke; van Heijst, Jeroen W. J.; Velds, Arno; Urbanus, Jos; Naik, Shalin H.; Jacobs, Heinz; Beltman, Joost B.; de Boer, Rob J.; Schumacher, Ton N. M.
Science (American Association for the Advancement of Science), 05/2013, Letnik: 340, Številka: 6132Journal Article
Upon infection, antigen-specific CD8⁺ T lymphocyte responses display a highly reproducible pattern of expansion and contraction that is thought to reflect a uniform behavior of individual cells. We tracked the progeny of individual mouse CD8⁺ T cells by in vivo lineage tracing and demonstrated that, even for T cells bearing identical T cell receptors, both clonal expansion and differentiation patterns are heterogeneous. As a consequence, individual naïve T lymphocytes contributed differentially to short- and long-term protection, as revealed by participation of their progeny during primary versus recall infections. The discordance in fate of individual naïve T cells argues against asymmetric division as a singular driver of CD8⁺ T cell heterogeneity and demonstrates that reproducibility of CD8⁺ T cell responses is achieved through population averaging.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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