Two conjugate sesquiterterpenes, a phenylpropanoid and an aporphine alkaloid were isolated in addition to several known compounds from cyclohexane, dichloromethane and alkaloid extracts of the bark of Pachypodanthium confine. The structures of these compounds were established based on interpretation of their high resolution NMR (HSQC, HMBC, COSY and NOESY) spectral data. Two sesquiterpene-trimethoxystyrene conjugates ( E)-1-3′-(4″,8″-dimethylnona-3″,7″-dienyl)cyclohex-3′-enyl-2,4,5-trimethoxybenzene ( 1) and ( Z)-1-3′-(4″,8″-dimethylnona-3″,7″-dienyl)cyclohex-3′-enyl-2,4,5-trimethoxybenzene ( 2), a phenylpropanoid 1,2,4-trimethoxy-5-(1-methoxy-ethyl)-benzene ( 3), and an aporphine alkaloid N-acetylpachypodanthine ( 4), were isolated in addition to several known compounds from cyclohexane, dichloromethane and alkaloid extracts from bark of Pachypodanthium confine. The structures of these compounds were established based on the interpretation of their high resolution NMR (HSQC, HMBC, COSY and NOESY) spectral data.