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Jensen, Christina T; Åhsberg, Josefine; Sommarin, Mikael N E; Strid, Tobias; Somasundaram, Rajesh; Okuyama, Kazuki; Ungerbäck, Jonas; Kupari, Jussi; Airaksinen, Matti S; Lang, Stefan; Bryder, David; Soneji, Shamit; Karlsson, Göran; Sigvardsson, Mikael
The Journal of experimental medicine, 07/2018, Letnik: 215, Številka: 7Journal Article
To understand the developmental trajectories in early lymphocyte differentiation, we identified differentially expressed surface markers on lineage-negative lymphoid progenitors (LPs). Single-cell polymerase chain reaction experiments allowed us to link surface marker expression to that of lineage-associated transcription factors (TFs) and identify GFRA2 and BST1 as markers of early B cells. Functional analyses in vitro and in vivo as well as single-cell gene expression analyses supported that surface expression of these proteins defined distinct subpopulations that include cells from both the classical common LPs (CLPs) and Fraction A compartments. The formation of the GFRA2-expressing stages of development depended on the TF EBF1, critical both for the activation of stage-specific target genes and modulation of the epigenetic landscape. Our data show that consecutive expression of Ly6D, GFRA2, and BST1 defines a developmental trajectory linking the CLP to the CD19 progenitor compartment.
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in: SICRIS
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