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Chau, Nguyen Van Vinh; Nguyet, Lam Anh; Dung, Nguyen Thanh; Quang, Vo Minh; Truong, Nguyen Thanh; Toan, Le Mau; Hung, Le Manh; Man, Dinh Nguyen Huy; Khoa, Dao Bach; Phong, Nguyen Thanh; Ngoc, Nghiem My; Thao, Huynh Phuong; Ty, Dinh Thi Bich; Thanh, Pham Ba; Ny, Nguyen Thi Han; Thanh, Le Kim; Thuy, Cao Thu; Anh, Nguyen To; Hong, Nguyen Thi Thu; Nhu, Le Nguyen Truc; Yen, Lam Minh; Thwaites, Guy; Thanh, Tran Tan; Tan, Le Van
The American journal of tropical medicine and hygiene, 01/2023, Letnik: 108, Številka: 1Journal Article
We studied the development and persistence of neutralizing antibodies against SARS-CoV-2 ancestral strain, and Delta and Omicron (BA.1 and BA.2) variants in Vietnamese healthcare workers (HCWs) up to 15 weeks after booster vaccination. We included 47 HCWs, including group 1 (G1, N = 21) and group 2 (G2; N = 26) without and with breakthrough Delta variant infection before booster immunization, respectively). The study participants had completed primary immunization with ChAdOx1-S and booster vaccination with BNT162b2. Neutralizing antibodies were measured using a surrogate virus neutralization assay. Of the 21 study participants in G1, neutralizing antibodies against ancestral strain, Delta variant, BA.1, and BA.2 were (almost) abolished at month 8 after the second dose, but all had detectable neutralizing antibodies to the study viruses at week 2 post booster dose. Of the 26 study participants in G2, neutralizing antibody levels to BA.1 and BA.2 were significantly higher than those to the corresponding viruses measured at week 2 post breakthrough infection and before the booster dose. At week 15 post booster vaccination, neutralizing antibodies to BA.1 and BA.2 dropped significantly, with more profound changes observed in those without breakthrough Delta variant infection. Booster vaccination enhanced neutralizing activities against ancestral strain and Delta variant compared with those induced by primary vaccination. These responses were maintained at high levels for at least 15 weeks. Our findings emphasize the importance of the first booster dose in producing cross-neutralizing antibodies against Omicron variant. A second booster to maintain long-term vaccine effectiveness against the currently circulating variants merits further research.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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