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Vazirani, Ravi; Feltes, Gisela; Hoyo, Rafael Sánchez-Del; Viana-Llamas, María C; Raposeiras-Roubín, Sergio; Romero, Rodolfo; Alfonso-Rodríguez, Emilio; Uribarri, Aitor; Santoro, Francesco; Becerra-Muñoz, Víctor; Pepe, Martino; Castro-Mejía, Alex F; Signes-Costa, Jaime; Gonzalez, Adelina; Marín, Francisco; Lopez-País, Javier; Cerrato, Enrico; Vázquez-Cancela, Olalla; Espejo-Paeres, Carolina; López Masjuan, Álvaro; Velicki, Lazar; El-Battrawy, Ibrahim; Ramakrishna, Harish; Fernandez-Ortiz, Antonio; Nuñez-Gil, Ivan J
Journal of clinical medicine, 05/2024, Letnik: 13, Številka: 9Journal Article
: Acute cardiac injury (ACI) after COVID-19 has been linked with unfavorable clinical outcomes, but data on the clinical impact of elevated cardiac troponin on discharge during follow-up are scarce. Our objective is to elucidate the clinical outcome of patients with elevated troponin on discharge after surviving a COVID-19 hospitalization. : We conducted an analysis in the prospective registry HOPE-2 (NCT04778020). Only patients discharged alive were selected for analysis, and all-cause death on follow-up was considered as the primary endpoint. As a secondary endpoint, we established any long-term COVID-19 symptoms. HOPE-2 stopped enrolling patients on 31 December 2021, with 9299 patients hospitalized with COVID-19, of which 1805 were deceased during the acute phase. Finally, 2382 patients alive on discharge underwent propensity score matching by relevant baseline variables in a 1:3 fashion, from 56 centers in 8 countries. : Patients with elevated troponin experienced significantly higher all-cause death during follow-up (log-rank = 27.23, < 0.001), and had a higher chance of experiencing long-term COVID-19 cardiovascular symptoms. Specifically, fatigue and dyspnea (57.7% and 62.8%, with -values of 0.009 and <0.001, respectively) are among the most common. After surviving the acute phase, patients with elevated troponin on discharge present increased mortality and long-term COVID-19 symptoms over time, which is clinically relevant in follow-up visits.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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