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Pubill‐Ulldemolins, Cristina; Sharma, Sunil V.; Cartmell, Christopher; Zhao, Jinlian; Cárdenas, Paco; Goss, Rebecca J. M.
Chemistry, August 14, 2019, Letnik: 25, Številka: 46Journal Article
The blending of synthetic chemistry with biosynthetic processes provides a powerful approach to synthesis. Biosynthetic halogenation and synthetic cross‐coupling have great potential to be used together, for small molecule generation, access to natural product analogues and as a tool for chemical biology. However, to enable enhanced generality of this approach, further synthetic tools are needed. Though considerable research has been invested in the diversification of phenylalanine and tyrosine, functionalisation of tryptophans thorough cross‐coupling has been largely neglected. Tryptophan is a key residue in many biologically active natural products and peptides; in proteins it is key to fluorescence and dominates protein folding. To this end, we have explored the Heck cross‐coupling of halo‐indoles and halo‐tryptophans in water, showing broad reaction scope. We have demonstrated the ability to use this methodology in the functionalisation of a brominated antibiotic (bromo‐pacidamycin), as well as a marine sponge metabolite, barettin. Aqueous Heck cross‐coupling of unprotected halo‐indoles and halo‐tryptophans, showing broad reaction scope is presented. We demonstrate application of this methodology in the functionalisation of a brominated antibiotic (bromo‐pacidamycin) and a marine sponge metabolite, barettin.
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