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Linguiti, Giovanna; Giannico, Francesco; D'Addabbo, Pietro; Pala, Angela; Caputi Jambrenghi, Anna; Ciccarese, Salvatrice; Massari, Serafina; Antonacci, Rachele
Genes, 01/2022, Letnik: 13, Številka: 2Journal Article
The domestic pig ( ) is a species representative of the Suina, one of the four suborders within Cetartiodactyla. In this paper, we reported our analysis of the pig TRG locus in comparison with the loci of species representative of the Ruminantia, Tylopoda, and Cetacea suborders. The pig TRG genomic structure reiterates the peculiarity of the organization of Cetartiodactyla loci in TRGC "cassettes", each containing the basic V-J-J-C unit. Eighteen genes arranged in four TRGC cassettes, form the pig TRG locus. All the functional genes were expressed, and the genes preferentially rearrange with the genes within their own cassette, which correlates the diversity of the γ-chain repertoire with the number of cassettes. Among them, the , located at the 5' end of the locus, is the only cassette that retains a marked homology with the corresponding TRGC cassettes of all the analyzed species. The preservation of the TRGC5 cassette for such a long evolutionary time presumes a highly specialized function of its genes, which could be essential for the survival of species. Therefore, the maintenance of this cassette in pigs confirms that it is the most evolutionarily ancient within Cetartiodactyla, and it has undergone a process of duplication to give rise to the other TRGC cassettes in the different artiodactyl species in a lineage-specific manner.
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