E-viri
Recenzirano
-
Bashashati, M.; Rezaei, N.; Shafieyoun, A.; McKernan, D. P.; Chang, L.; Öhman, L.; Quigley, E. M.; Schmulson, M.; Sharkey, K. A.; Simrén, M.
Neurogastroenterology and motility, July 2014, Letnik: 26, Številka: 7Journal Article
Background Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder of unknown etiology; although infection and inflammation have recently been considered as important etiologic agents. A recent meta‐analysis showed correlations between cytokine interleukin‐10 (IL‐10) and tumor necrosis factor (TNF) gene polymorphisms and IBS; however, it is still unknown whether patients with IBS have different cytokine profiles compared to healthy population. Methods To determine the relationships between serum/plasma levels or mucosal expression of IL‐10/TNF‐α and IBS, we conducted a systematic review and meta‐analysis based on case–control studies retrieved from PubMed and EMBASE search through August 2013. Standardized mean difference (SMD) was generated by using the inverse variance method. Heterogeneity was assessed based on I2 values. Key Results Serum/plasma levels of TNF‐α tended to be higher in IBS vs controls (p = 0.09); this reached significance in IBS subtypes vs controls and in female patients with IBS. However, serum/plasma levels of IL‐10 were not significantly different in IBS patients vs controls. Further analysis of serum/plasma IL‐10 levels in IBS subtypes did not show any difference; however, analysis based on gender showed a significantly lower serum/plasma IL‐10 levels in male patients with IBS vs male controls (p = 0.02). Colonic IL‐10 mRNA had a significantly lower expression in IBS vs control (p = 0.001). Conclusions & Inferences There is an imbalance of proinflammatory TNF‐α, and anti‐inflammatory IL‐10, cytokines in IBS. Stratifying IBS patients based on cytokine profile may represent an opportunity for personalized treatment of this condition. There is an imbalance of proinflammatory TNF‐α, and anti‐inflammatory IL‐10, cytokines in IBS. This figure shows circulating TNF‐α levels based on IBS subtypes in patients vs healthy controls. Stratifying IBS patients based on cytokine profile may represent an opportunity for personalized treatment of this condition.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.