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Hedderich, Jürgen; Nikolaus, Susanna; Schuldt, Dörthe; Schreiber, Stefan; Lu, Tim; Franke, Andre; Rosenstiel, Philip; Karlsen, Tom H; Balschun, Tobias; May, Sandra; Krawczak, Michael
Nature genetics, 06/2008, Letnik: 40, Številka: 6Journal Article
Following up on recent genome-wide association studies (GWAS) of Crohn's disease, we investigated 50 previously reported susceptibility loci in a German sample of individuals with Crohn's disease (n = 1,850) or ulcerative colitis (n = 1,103) and healthy controls (n = 1,817). Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection.
