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Sandhu, Manjinder S; Barroso, Inês; Weedon, Michael N; Fawcett, Katherine A; Wasson, Jon; Debenham, Sally L; Daly, Allan; Lango, Hana; Frayling, Timothy M; Neumann, Rosalind J; Sherva, Richard; Blech, Ilana; Pharoah, Paul D; Palmer, Colin N A; Kimber, Charlotte; Tavendale, Roger; Morris, Andrew D; McCarthy, Mark I; Walker, Mark; Hitman, Graham; Glaser, Benjamin; Permutt, M Alan; Hattersley, Andrew T; Wareham, Nicholas J
Nature genetics, 08/2007, Letnik: 39, Številka: 8Journal Article
We studied genes involved in pancreatic β cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes.
