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Lantuejoul, Sylvie; Sound-Tsao, Ming; Cooper, Wendy A.; Girard, Nicolas; Hirsch, Fred R.; Roden, Anja C.; Lopez-Rios, Fernando; Jain, Deepali; Chou, Teh-Ying; Motoi, Noriko; Kerr, Keith M.; Yatabe, Yasushi; Brambilla, Elisabeth; Longshore, John; Papotti, Mauro; Sholl, Lynette M.; Thunnissen, Erik; Rekhtman, Natasha; Borczuk, Alain; Bubendorf, Lukas; Minami, Yuko; Beasley, Mary Beth; Botling, Johan; Chen, Gang; Chung, Jin-Haeng; Dacic, Sanja; Hwang, David; Lin, Dongmei; Moreira, Andre; Nicholson, Andrew G.; Noguchi, Masayuki; Pelosi, Giuseppe; Poleri, Claudia; Travis, William; Yoshida, Akihiko; Daigneault, Jillian B.; Wistuba, Ignacio I.; Mino-Kenudson, Mari
Journal of thoracic oncology, 2020-April, Letnik: 15, Številka: 4Journal Article
The recent development of immune checkpoint inhibitors (ICIs) has led to promising advances in the treatment of patients with NSCLC and SCLC with advanced or metastatic disease. Most ICIs target programmed cell death protein 1 (PD-1) or programmed death ligand 1 (PD-L1) axis with the aim of restoring antitumor immunity. Multiple clinical trials for ICIs have evaluated a predictive value of PD-L1 protein expression in tumor cells and tumor-infiltrating immune cells (ICs) by immunohistochemistry (IHC), for which different assays with specific IHC platforms were applied. Of those, some PD-L1 IHC assays have been validated for the prescription of the corresponding agent for first- or second-line treatment. However, not all laboratories are equipped with the dedicated platforms, and many laboratories have set up in-house or laboratory-developed tests that are more affordable than the generally expensive clinical trial–validated assays. Although PD-L1 IHC test is now deployed in most pathology laboratories, its appropriate implementation and interpretation are critical as a predictive biomarker and can be challenging owing to the multiple antibody clones and platforms or assays available and given the typically small size of samples provided. Because many articles have been published since the issue of the IASLC Atlas of PD-L1 Immunohistochemistry Testing in Lung Cancer, this review by the IASLC Pathology Committee provides updates on the indications of ICIs for lung cancer in 2019 and discusses important considerations on preanalytical, analytical, and postanalytical aspects of PD-L1 IHC testing, including specimen type, validation of assays, external quality assurance, and training.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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