E-viri
Recenzirano
Odprti dostop
-
O'Donnell, Lara; Panier, Stephanie; Wildenhain, Jan; Tkach, Johnny M.; Al-Hakim, Abdallah; Landry, Marie-Claude; Escribano-Diaz, Cristina; Szilard, Rachel K.; Young, Jordan T.F.; Munro, Meagan; Canny, Marella D.; Kolas, Nadine K.; Zhang, Wei; Harding, Shane M.; Ylanko, Jarkko; Mendez, Megan; Mullin, Michael; Sun, Thomas; Habermann, Bianca; Datti, Alessandro; Bristow, Robert G.; Gingras, Anne-Claude; Tyers, Michael D.; Brown, Grant W.; Durocher, Daniel
Molecular cell, 11/2010, Letnik: 40, Številka: 4Journal Article
Genome integrity is jeopardized each time DNA replication forks stall or collapse. Here we report the identification of a complex composed of MMS22L (C6ORF167) and TONSL (NFKBIL2) that participates in the recovery from replication stress. MMS22L and TONSL are homologous to yeast Mms22 and plant Tonsoku/Brushy1, respectively. MMS22L-TONSL accumulates at regions of ssDNA associated with distressed replication forks or at processed DNA breaks, and its depletion results in high levels of endogenous DNA double-strand breaks caused by an inability to complete DNA synthesis after replication fork collapse. Moreover, cells depleted of MMS22L are highly sensitive to camptothecin, a topoisomerase I poison that impairs DNA replication progression. Finally, MMS22L and TONSL are necessary for the efficient formation of RAD51 foci after DNA damage, and their depletion impairs homologous recombination. These results indicate that MMS22L and TONSL are genome caretakers that stimulate the recombination-dependent repair of stalled or collapsed replication forks. Display omitted ► Loss of MMS22L or TONSL results in spontaneous DNA double-strand breaks ► MMS22L forms an interdependent complex with TONSL ► MMS22L and TONSL accumulate at lesions containing RPA-bound single-stranded DNA ► MMS22L-TONSL promotes RAD51 nucleofilament formation and homologous recombination
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.