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Sugama, Shuei; Sekiyama, Kazunari; Kodama, Tohru; Takamatsu, Yoshiki; Takenouchi, Takato; Hashimoto, Makoto; Bruno, Conti; Kakinuma, Yoshihiko
Brain, behavior, and immunity, 01/2016, Letnik: 51Journal Article
Highlights • The present study investigated the effects of chronic stress on dopaminergic neurodegeneration. • The chronic stress significantly triggered the dopaminergic neuron loss in the substantia nigra. • The chronic stress also reduced noradrenergic neuron in the locus coeruleus. • The activated microglia induced by stress exposures is detected in the substantia nigra and locus coeruleus. • Nitrotyrosine as a marker of oxidative stress is also significantly increased in the substantia nigra and locus coeruleus.
