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Marinković, Sonja T; Đukanović, Đorđe; Duran, Mladen; Bajic, Zorislava; Sobot, Tanja; Uletilović, Snežana; Mandić-Kovacević, Nebojša; Cvjetković, Tanja; Maksimović, Žana M; Maličević, Uglješa; Vesić, Nikolina; Jovičić, Sanja; Katana, Maja; Šavikin, Katarina; Djuric, Dragan M; Stojiljković, Miloš P; Škrbić, Ranko
Pharmaceutics, 06/2023, Letnik: 15, Številka: 6Journal Article
Takotsubo syndrome (TTS) is an acute heart failure syndrome characterised by catecholamine-induced oxidative tissue damage. , a fruit-bearing tree, is known to have high polyphenolic content and has been proven to be a potent antioxidant. This study aimed to investigate the effects of pomegranate peel extract (PoPEx) pre-treatment on isoprenaline-induced takotsubo-like myocardial injury in rats. Male Wistar rats were randomised into four groups. Animals in the PoPEx(P) and PoPEx + isoprenaline group (P + I) were pre-treated for 7 days with 100 mg/kg/day of PoPEx. On the sixth and the seventh day, TTS-like syndrome was induced in rats from the isoprenaline(I) and P + I groups by administering 85 mg/kg/day of isoprenaline. PoPEx pre-treatment led to the elevation of superoxide dismutase and catalase ( < 0.05), reduced glutathione ( < 0.001) levels, decreased the thiobarbituric acid reactive substances ( < 0.001), H O , O ( < 0.05), and NO ( < 0.001), in the P + I group, when compared to the I group. In addition, a significant reduction in the levels of cardiac damage markers, as well as a reduction in the extent of cardiac damage, was found. In conclusion, PoPEx pre-treatment significantly attenuated the isoprenaline-induced myocardial damage, primarily via the preservation of endogenous antioxidant capacity in the rat model of takotsubo-like cardiomyopathy.
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