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Tucci, Alessandra; Martelli, Maurizio; Rigacci, Luigi; Riccomagno, Paola; Cabras, Maria Giuseppina; Salvi, Flavia; Stelitano, Caterina; Fabbri, Alberto; Storti, Sergio; Fogazzi, Stefano; Mancuso, Salvatrice; Brugiatelli, Maura; Fama, Angelo; Paesano, Paolo; Puccini, Benedetta; Bottelli, Chiara; Dalceggio, Daniela; Bertagna, Francesco; Rossi, Giuseppe; Spina, Michele
Leukemia & lymphoma, 04/2015, Letnik: 56, Številka: 4Journal Article
Abstract We performed a multicenter study to validate the concept that a simple comprehensive geriatric assessment (CGA) can identify elderly, non-fit patients with diffuse large B-cell lymphoma (DLBCL) in whom curative treatment is not better then palliation, and to analyze potential benefits of treatment modulation after further subdividing the non-fit category by CGA criteria. One hundred and seventy-three patients aged > 69 treated with curative or palliative intent by clinical judgement only were grouped according to CGA into fit (46%), unfit (16%) and frail (38%) categories. Two-year overall survival (OS) was significantly better in fit than in non-fit patients (84% vs. 47%; p < 0.0001). Survival in unfit and frail patients was not significantly different. Curative treatment slightly improved 2-year OS in unfit (75% vs. 45%) but not in frail patients (44% vs. 39%). CGA was confirmed as very efficient in identifying elderly patients with DLBCL who can benefit from a curative approach. Further efforts are needed to better tailor therapies in non-fit patients.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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