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Duan, Hongying; Corrigan, Angela R.; Cheng, Cheng; Biju, Andrea; Gonelli, Christopher A.; Olia, Adam S.; Teng, I-Ting; Xu, Kai; O’Dell, Sijy; Narpala, Sandeep; Castro, Mike; Serebryannyy, Leonid; Wang, Jennifer; Parchment, Danealle K.; Sarfo, Edward K.; van Schooten, Jelle; Todd, John-Paul; Wang, Shuishu; Harris, Darcy R.; Geng, Hui; Jafari, Alexander J.; Woodward, Ruth A.; Doria-Rose, Nicole A.; Foulds, Kathryn E.; McDermott, Adrian B.; van Gils, Marit J.; Koup, Richard A.; Pierson, Theodore C.; Kwong, Peter D.; Mascola, John R.
iScience, 02/2024, Letnik: 27, Številka: 2Journal Article
Soluble ‘SOSIP’-stabilized HIV-1 envelope glycoprotein (Env) trimers elicit dominant antibody responses targeting their glycan-free base regions, potentially diminishing neutralizing responses. Previously, using a nonhuman primate model, we demonstrated that priming with fusion peptide (FP)-carrier conjugate immunogens followed by boosting with Env trimers reduced the anti-base response. Further, we demonstrated that longer immunization intervals further reduced anti-base responses and increased neutralization breadth. Here, we demonstrate that long trimer-boosting intervals, but not long FP immunization intervals, reduce the anti-base response. Additionally, we identify that FP priming before trimer immunization enhances antibody avidity to the Env trimer. We also establish that adjuvants Matrix M and Adjuplex further reduce anti-base responses and increase neutralizing titers. FP priming, long trimer-immunization interval, and an appropriate adjuvant can thus reduce anti-base antibody responses and improve Env-directed vaccine outcomes. Display omitted •We identify factors that improve or impact Env-directed HIV-1-vaccine outcomes•Long Env trimer interval, but not long FP interval, reduces anti-base responses•FP priming prior to trimer immunization increases antibody avidity to trimer•Adjuvants impact anti-base and epitope-specific immune responses Immune response; Virology; Immunology
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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