Background:Routine assessment of patient index data 3 (RAPID3) is a simplified measure of disease activity in Rheumatoid Arthritis (RA) constituting an index that is based only upon patient self-reported outcomes and so is simpler in terms of administration. So closely spaced domicilliary monitoring using RAPID 3 may allow the early detection of relapses.Objectives:1. To assess the disease activity in rheumatoid arthritis on fortnightly basis using RAPID 3.2. To assess disease activity using DAS 28 (disease activity score), CDAI (clinical disease activity index) every 2 monthsMethods:The present study was a follow up study done on ninety four RA patients (as per American college of Rheumatology criteria ACR criteria) who presented between February 2019 to February 2020 in Rheumatology clinic at our institution Pandit B.D.Sharma PGIMS, Rohtak in. Patients were assessed in the clinic for disease activity using Disease activity score-28 (DAS28) and Clinical disease activity index (CDAI) at baseline, two months and four months. In addition, RAPID 3 score was assessed by subjects themselves fortnightly (on domicillary basis) till four months.Results:Mean age of the subjects was 41.37 ± 11.09 years with 88 females and 6 males. At baseline the mean DAS28, CDAI and RAPID 3 scores were 4.98±0.7, 26.48±8.2and 15.03±4.9; at two months were 4.87±0.8, 25.14±10.0 and 14.01±4.8; at four months 4.48±0.9, 19.12±8.9 and 9.66±3.3 respectively. Pearson’s Correlation Coefficients of RAPID 3 score with DAS28 and CDAI scores at baseline were 0.651 and 0.795, at two months were 0.755 and 0.808 and at four months were 0.796 and 0.805 respectively (all p-value <0.001). Reliability index (as assessed by Cronbach’s alpha) for RAPID 3 score, DAS28 and CDAI were 0.769, 0.50, 0.744 at baseline and 0.78, 0.58, 0.80 at two months and 0.642, 0.659, 0.654 at four months respectively. The mean values of RAPID 3 score and its domains fluctuated till 2 months (not identified by conventional DAS 28 & CDAI) thereafter decreased with treatment in four months of followup.Conclusion:RAPID 3 score was found having significant correlation with DAS28 and CDAI. The fortnightly assessment of disease activity done at home identified the subtle changes in disease activity which were not identified during routine checkups in the clinic. So, RAPID 3 Score as a patient reported outcome in disease activity assessment in RA proved to be a good tool and its use on domiciliary basis helps the patient and physician in targeting the disease effectively.REFERENCES:NIL.Table 1.Mean values of Routine assessment of patient index data 3 (RAPID 3) score and its individual variablesTIMEVARIABLESRAPID 3 (Mean ± SD)Physical functionPainPatient global assessmentMean ± SDMean± SDMean ± SDBaseline3.9915 ± 2.435655.069 ± 1.91015.98 ± 1.51715.0394 ± 4.9383615 days3.8851 ± 2.299184.457 ± 2.16734.373 ± 2.052012.7266 ± 5.810731month3.9617 ± 2.492404.489 ± 2.04384.452 ± 2.001412.9191 ± 5.816041m15 days3.8968 ± 2.402984.431 ± 2.00894.457 ± 1.953312.7851 ± 5.689002months3.9223 ± 2.365814.723 ± 1.68905.73 ± 1.78514.0128 ± 4.888882m15 days3.3510 ± 1.940704.074 ± 1.83453.80 ± 1.80011.3074 ± 5.365273months3.0702 ± 1.604623.748 ± 1.63573.707 ± 1.564710.5117 ± 4.469443m 15 days2.8862 ± 1.692533.57 ± 1.6163.489 ± 1.49919.9713 ± 4.324914months2.5862 ± 1.610423.60 ± 1.6023.47 ± 1.1339.6606 ± 3.39871P VALUES0.002<0.001<0.001<0.001Table 2.Correlation coefficients for DAS28 and CDAI with RAPID3 scoreDisease activity scoreCorrelation coefficientsAt BaselineAt 2 monthsAt 4 monthsP valueDAS28 & RAPID 30.6710.7550.796<0.001CDAI & RAPID 30.7950.8080.805Acknowledgements:I would like to express my sincere gratitude first to almighty and my parents. Special thanks to my mentor Dr Harpreet Singh who was always there from the beginning to execution. Additionally, I extend my appreciation to my colleagues, juniors and seniors who provided support and resources. Their contributions have significantly enriched the quality of this work.Disclosure of Interests:None declared.