With the computer center's move came an upgrade giving its main "cluster," called U2, a capacity of 13 trillion calculations per second. The upgrade came after the computer was already ranked at number 87 on the widely watched Top500.org list of the world's fastest machines. Even so, the ranking puts U2 among an exclusive group of government research labs and a few top universities in terms of computing power. Hosting the supercomputer marks another milestone in the development of the 150,000-square-foot bioinformatics center, officials said. Announced with fanfare by former Gov. George Pataki in 2001, the four-story center is the middle of a $200 million trio of research buildings at Virginia and Ellicott streets, bracketed by the Hauptman Woodward Medical Research Institute and Roswell Park Cancer Institute's gene research center. With its combination of labs, offices and now computing power, the bioinformatics center is a place where scientific research can meet the business culture necessary to get discoveries from the lab to the bedside, he said. Next door to Bruce Holm's office on the center's top floor is space for biotech management consultants from Buffalo Biosciences LLC, a commercialization consultant.