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Cerdó, Tomás; Ruiz-Rodríguez, Alicia; Acuña, Inmaculada; Torres-Espínola, Francisco José; Menchén-Márquez, Sergio; Gámiz, Fernando; Gallo, Milagros; Jehmlich, Nico; Haange, Sven-Bastiaan; von Bergen, Martin; Campoy, Cristina; Suárez, Antonio
Cell host & microbe, 12/2023, Letnik: 31, Številka: 12Journal Article
Gut microbiota has been linked to infant neurodevelopment. Here, an association between infant composite cognition and gut microbiota composition is established as soon as 6 months. Higher diversity and evenness characterize microbial communities of infants with composite cognition above (Inf-aboveCC) versus below (Inf-belowCC) median values. Metaproteomic and metabolomic analyses establish an association between microbial histidine ammonia lyase and infant histidine metabolome with cognition. Fecal transplantation from Inf-aboveCC versus Inf-belowCC donors into germ-free mice shows that memory, assessed by a novel object recognition test, is a transmissible trait. Furthermore, Inf-aboveCC mice are enriched in species belonging to Phocaeicola, as well as Bacteroides and Bifidobacterium, previously linked to cognition. Finally, Inf-aboveCC mice show lower fecal histidine and urocanate:histidine and urocanate:glutamate ratios in the perirhinal cortex compared to Inf-belowCC mice. Overall, these findings reveal a causative role of gut microbiota on infant cognition, pointing at the modulation of histidine metabolite levels as a potential underlying mechanism.
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