Objectives: It was known that oxidative/antioxidative balance shifted to oxidative side in patients with coronary artery disease. The aim of this study is to evaluate the relationship between coronary artery disease and total antioxidant status, oxidative stress index. Materials and methods: The study group consisted of 87 consecutive patients who were hospitalized for coronary angiography. Plasma total oxidative status (TOS) and total antioxidative capacity (TAC) levels were measured and oxidative stress index (OSI) was calculated. Results: The TAC values increased statistically significant in the four tertile compared with the first tertile (1.9 ± 0.2 vs 2.0 ± 0.2 mmol Trolox Eq/l) and the TOS values decreased non- significantly in the four tertile ( 5.2 ± 2.8 vs 7.2 ± 5.4 µmol H2O2 Eq/l) as compared to the patients in the first tertile. According to the number of diseased vessels, plasma oxidative characteristics did not differ between the three groups. Conclusions: Plasma TAC levels increased in subjects with coronary atherosclerosis and severity of coronary atherosclerosis is related with TAC.