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Zeng, Ting; Liang, Yanshan; Chen, Jinyao; Cao, Guodong; Yang, Zhu; Zhao, Xingchen; Tian, Jinglin; Xin, Xiong; Lei, Bo; Cai, Zongwei
Environment international, September 2021, 2021-09-00, 20210901, 2021-09-01, Letnik: 154Journal Article
Display omitted •Urines from female and male residents under cadmium exposure were investigated by mass spectrometry-based metabolomics.•Biomarkers and metabolic pathways related to cadmium-induced nephrotoxicity were characterized.•This study might provide information to reflect the body burden and help improve health policy for risk assessment. Cadmium is a well-known hazardous pollutant that mainly comes from dietary, tobacco and occupational exposure, posing threat to kidney. However, there is still a lack of systematic study on metabolic pathways and urinary biomarkers related to its nephrotoxicity under cadmium exposure for both females and males. In this study, a mass spectrometry-based metabolomics investigation of a cohort of 144 volunteers was conducted to explore sex-specific metabolic alteration and to screen biomarkers related to cadmium-induced nephrotoxicity. When the concentration of urinary cadmium increased, creatine pathway, amino acid metabolism especially the tryptophan metabolism, aminoacyl-tRNA biosynthesis, and purine metabolism were primarily influenced regardless of the gender. Also, the most specific biomarkers linked with nephrotoxicity based on the statistical analysis were detected including creatine, creatinine, l-tryptophan, adenine and uric acid. The study outcome might provide information to reflect the body burden and help improve health policy for risk assessment.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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