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Polak, Katarzyna; Marchal, Patricia; Taroni, Chiara; Ebel, Claudine; Kirstetter, Peggy; Kastner, Philippe; Chan, Susan
Biochemical and biophysical research communications, 09/2023, Letnik: 674Journal Article
The transcriptional regulators that drive regulatory T (Treg) cell development and function remain partially understood. Helios (Ikzf2) and Eos (Ikzf4) are closely-related members of the Ikaros family of transcription factors. They are highly expressed in CD4+ Treg cells and functionally important for Treg cell biology, as mice deficient for either Helios or Eos are susceptible to autoimmune diseases. However, it remains unknown if these factors exhibit specific or partially redundant functions in Treg cells. Here we show that mice with germline deletions of both Ikzf2 and Ikzf4 are not very different from animals with single Ikzf2 or Ikzf4 deletions. Double knockout Treg cells differentiate normally, and efficiently suppress effector T cell proliferation in vitro. Both Helios and Eos are required for optimal Foxp3 protein expression. Surprisingly, Helios and Eos regulate different, largely non-overlapping, sets of genes. Only Helios is required for proper Treg cell aging, as Helios deficiency results in reduced Treg cell frequencies in the spleen of older animals. These results indicate that Helios and Eos are required for distinct aspects of Treg cell function. •Mice lacking both Helios and Eos have unimpaired Treg cell development.•Both Eos and Helios are required for optimal Foxp3 expression.•Age dependent increase in Treg cell frequency is dependent on Helios.•Helios and Eos control distinct transcriptional programs in Treg cells.•Helios deficient Treg cells have an activated gene expression signature.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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