Zirconium oxide (ZrO ) is the general material in dental area, with natural color, high toughness and strength. Recent years, small blocks of ZrO such as micro/nano powders have been studied and developed widely. Nano scale ZrO , which show simproved mechanical characteristics and superior biocompatibility, are usually incorporated into different applications used in dentistry and tissue engineering. This review provides an overview of nano-ZrO materials and its applications in dentistry. The synthesis of nano-ZrO powders were mainly prepared by coprecipitation, hydrothermal method and sol-gel method. Then different applications of nano-ZrO biomaterials in dental ceramics, implants, radio pacifying agents, basement and tissue engineering fields were briefly introduced.