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Schafzahl, Bettina; Knall, Astrid C.; Slugovc, Christian
Monatshefte für Chemie, 12/2023, Letnik: 154, Številka: 12Journal Article
Inverse electron-demand Diels–Alder additions (iEDDA) between 1,2,4,5-tetrazines and suitable unsaturated dienophiles such as olefins, alkynes, or enol ethers provide facile access to pyridazines. Herein the use of cyclic enol ether derivatives for preparing pyridazines bearing 2-hydroxyethyl, 3-hyproxypropyl, and 3-oxopropyl substituents at the 4-position is disclosed and second order rate constants for the reactions with 2,3-dihydrofuran, 3,4-dihydro-2 H -pyran, and 2-methoxy-3,4-dihydro-2 H -pyran are presented. Graphical abstract
