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Smillie, Christopher S.; Biton, Moshe; Ordovas-Montanes, Jose; Sullivan, Keri M.; Burgin, Grace; Graham, Daniel B.; Herbst, Rebecca H.; Rogel, Noga; Slyper, Michal; Waldman, Julia; Sud, Malika; Andrews, Elizabeth; Velonias, Gabriella; Haber, Adam L.; Jagadeesh, Karthik; Vickovic, Sanja; Yao, Junmei; Stevens, Christine; Dionne, Danielle; Nguyen, Lan T.; Villani, Alexandra-Chloé; Hofree, Matan; Creasey, Elizabeth A.; Huang, Hailiang; Rozenblatt-Rosen, Orit; Garber, John J.; Khalili, Hamed; Desch, A. Nicole; Daly, Mark J.; Ananthakrishnan, Ashwin N.; Shalek, Alex K.; Xavier, Ramnik J.; Regev, Aviv
Cell, 07/2019, Letnik: 178, Številka: 3Journal Article
Genome-wide association studies (GWAS) have revealed risk alleles for ulcerative colitis (UC). To understand their cell type specificities and pathways of action, we generate an atlas of 366,650 cells from the colon mucosa of 18 UC patients and 12 healthy individuals, revealing 51 epithelial, stromal, and immune cell subsets, including BEST4+ enterocytes, microfold-like cells, and IL13RA2+IL11+ inflammatory fibroblasts, which we associate with resistance to anti-TNF treatment. Inflammatory fibroblasts, inflammatory monocytes, microfold-like cells, and T cells that co-express CD8 and IL-17 expand with disease, forming intercellular interaction hubs. Many UC risk genes are cell type specific and co-regulated within relatively few gene modules, suggesting convergence onto limited sets of cell types and pathways. Using this observation, we nominate and infer functions for specific risk genes across GWAS loci. Our work provides a framework for interrogating complex human diseases and mapping risk variants to cell types and pathways. Display omitted •51 cell subsets in colon mucosa of 18 ulcerative colitis and 12 healthy individuals•M-like cells, inflammatory monocytes and fibroblasts, and CD8+IL-17+ T cells expand in disease•Oncostatin M circuit in inflammatory monocytes and fibroblasts may affect drug response•Co-expression of genes within cells allows inference of causal genes across risk loci Single-cell analyses of colon biopsy specimens from patients with ulcerative colitis delineate how expression patterns and shifting cell populations may shape disease and drug resistance, and provide a framework for linking GWAS risk loci with specific cell types and functional pathways.
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in: SICRIS
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