We present and interpret newly determined site motions derived from GPS observations made from 2008 through 2016 in the Republic of Georgia, which constrain the rate and locus of active shortening in the Lesser–Greater Caucasus continental collision zone. Observation sites are located along two ∼160 km-long profiles crossing the Lesser–Greater Caucasus boundary zone: one crossing the Rioni Basin in western Georgia and the other crossing further east near the longitude of Tbilisi. Convergence across the Rioni Basin Profile occurs along the southern margin of the Greater Caucasus, near the surface trace of the north-dipping Main Caucasus Thrust Fault (MCTF) system, and is consistent with strain accumulation on the fault that generated the 1991 MW6.9 Racha earthquake. In contrast, convergence along the Tbilisi Profile occurs near Tbilisi and the northern boundary of the Lesser Caucasus (near the south-dipping Lesser Caucasus Thrust Fault), approximately 50–70 km south of the MCTF, which is inactive within the resolution of geodetic observations (<±0.5 mm/yr) at the location of the Tbilisi Profile. We suggest that the southward offset of convergence along strike of the range is related to the incipient collision of the Lesser–Greater Caucasus, and closing of the intervening Kura Basin, which is most advanced along this segment of the collision zone. The identification of active shortening near Tbilisi requires a reevaluation of seismic hazards in this area. •GPS observations quantify active crustal shortening in Georgian Caucasus Mountains.•Shortening is focused in the Lesser–Greater Caucasus continental collision zone.•Deformation is consistent with strain accumulation on range-parallel thrusts.•Shortening steps south near the Lesser–Greater Caucasus incipient collision.•Implications for seismic hazards require reevaluation in light of these observations.