•Presents a Delphi study of the challenges of big data analytics.•Provides in-depth background to the challenges via interviews with major big data enterprises.•Provides insight into analytics as a complex socio-technical entanglement.•Develops an analytics eco-system framework.•Gives practical guidance to managers about how they can navigate the organizational journey to becoming data-driven. The popularity of big data and business analytics has increased tremendously in the last decade and a key challenge for organizations is in understanding how to leverage them to create business value. However, while the literature acknowledges the importance of these topics little work has addressed them from the organization's point of view. This paper investigates the challenges faced by organizational managers seeking to become more data and information-driven in order to create value. Empirical research comprised a mixed methods approach using (1) a Delphi study with practitioners through various forums and (2) interviews with business analytics managers in three case organizations. The case studies reinforced the Delphi findings and highlighted several challenge focal areas: organizations need a clear data and analytics strategy, the right people to effect a data-driven cultural change, and to consider data and information ethics when using data for competitive advantage. Further, becoming data-driven is not merely a technical issue and demands that organizations firstly organize their business analytics departments to comprise business analysts, data scientists, and IT personnel, and secondly align that business analytics capability with their business strategy in order to tackle the analytics challenge in a systemic and joined-up way. As a result, this paper presents a business analytics ecosystem for organizations that contributes to the body of scholarly knowledge by identifying key business areas and functions to address to achieve this transformation.