The study of the level and quality of life, especially in cross-border regions, is one of the current research problems, bearing in mind the pursuit of socio-economic convergence. One of these regions with relatively little knowledge about the situation is the Volyn Oblast (Ukraine), which borders directly on the EU (Poland). Therefore, the main goal of the research is to diagnose the level and quality of life of the population, considering statistical measures and materials of field study. The results of the research indicate that the standard of living of the Volyn Oblast could be estimated as low in comparison with average values for Ukraine as well as in the light of selected measures of stimulants and de-stimulants. The obtained results were also confirmed by field research in randomly selected administrative units of the region.