This paper presents a new approach to controlling MIMO processes by using the double-loop multi-scale control scheme in the decentralized control architecture. The decentralized PID control system has been used in process industry despite its several limitations due to process interactions, time-delays and right half plane poles. To overcome the performance limitation due to process interactions, decoupling controllers are often added to the decentralized PID control system. The proposed strategy based on the double-loop multi-scale control scheme has some advantages over the existing control strategies for MIMO processes. An advantage of the proposed scheme over the decentralized PID control with decoupling system is that, the proposed strategy has a fixed number of dimensionless tuning parameters that are easy to tune. For an n×n MIMO process, the proposed scheme requires the tuning of only 3 to 6 dimensionless parameters instead of the 3n original PID parameters.