Coronary artery disease (CAD) involves a complex atherosclerotic process, and many factors play a role in this process. Although there are studies evaluating the development and severity of CAD with trace elements in the blood, there is no study evaluating coronary flow to our knowledge. This study aimed to evaluate the relationship between coronary flow and trace elements after percutaneous intervention in ST-elevation myocardial infarction (STEMI). This study included 126 consecutive patients who presented to the emergency department with STEMI between May 2023 and August 2023. Thrombolysis in myocardial infarction (TIMI) flow grades were calculated after primary percutaneous coronary intervention, and patients were categorized into two groups: low TIMI flow grade and normal TIMI flow grade. The diagnosis of STEMI was defined according to European acute coronary syndrome (ACS) guidelines. Demographic and clinical data were recorded. After coronary angiography, blood tests for trace elements were obtained in addition to routine laboratory parameters. All variables were compared between the two groups. There was no significant difference between low and normal TIMI flow grade groups regarding age and gender. Killip score (p=0.004) and tirofiban (p<0.001) use were higher in the low TIMI flow grade group. Serum copper, high-density lipoprotein, low-density lipoprotein, diabetes mellitus, hypertension, and platelet variables were included in binary logistic regression analysis; low serum copper (p=0.014, OR=1.023, Cl=1.005-1.042) was found to be a risk factor for low TIMI flow grade. Regarding the outcomes of this research, we found that serum copper levels are an important risk factor for low TIMI flow grade in STEMI.