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Holland, Rachel; Leff, Alex P.; Josephs, Oliver; Galea, Joseph M.; Desikan, Mahalekshmi; Price, Cathy J.; Rothwell, John C.; Crinion, Jennifer
CB/Current biology, 08/2011, Letnik: 21, Številka: 16Journal Article
Electrophysiological studies in humans and animals suggest that noninvasive neurostimulation methods such as transcranial direct current stimulation (tDCS) can elicit long-lasting 1, polarity-dependent 2 changes in neocortical excitability. Application of tDCS can have significant and selective behavioral consequences that are associated with the cortical location of the stimulation electrodes and the task engaged during stimulation 3–8. However, the mechanism by which tDCS affects human behavior is unclear. Recently, functional magnetic resonance imaging (fMRI) has been used to determine the spatial topography of tDCS effects 9–13, but no behavioral data were collected during stimulation. The present study is unique in this regard, in that both neural and behavioral responses were recorded using a novel combination of left frontal anodal tDCS during an overt picture-naming fMRI study. We found that tDCS had significant behavioral and regionally specific neural facilitation effects. Furthermore, faster naming responses correlated with decreased blood oxygen level-dependent (BOLD) signal in Broca's area. Our data support the importance of Broca's area within the normal naming network and as such indicate that Broca's area may be a suitable candidate site for tDCS in neurorehabilitation of anomic patients, whose brain damage spares this region. ► This is a novel application of concurrent A-tDCS and fMRI during speech production ► Left frontal A-tDCS speeds up spoken naming responses ► Left frontal A-tDCS elicits a regionally specific neural effect in Broca's area ► Decreased BOLD signal in Broca's area correlates with faster naming responses
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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