Obesity has been linked to job absenteeism and decreased job performance. Additionally, shift work may be related to abnormal eating in nurses. This study examines the relationship between body mass index, job performance, absenteeism, and eating disorder risk among nurses. Registered Nurses (n = 63) participated in a survey that included the Work Limitations Questionnaire and the Eating Attitudes Test. Most participants were either overweight or obese. Significant correlations were noted between body mass index and job performance, and body mass index and risk of eating disorders. An understanding of how increased body mass index can affect a nurse's job performance and wellness warrants continued attention from the nursing profession. •Half of all study participants were either overweight, obese or severely obese.•Positive correlations were noted between nurse BMI and job performance.•Positive correlations were noted between nurse BMI and risk of eating disorder.•Nurses with overweight/obese BMIs had greater productivity loss scores.