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Porter, Joanna C; Win, Thida; Erlandsson, Kjell; Thielemans, Kris; Groves, Ashley M
The European respiratory journal, 03/2022, Letnik: 59, Številka: 3Journal Article
We thank P-S. Bellaye and co-workers for their considered and insightful response. Given their finding of 18 Ffluoromisonidazole ( 18 FF-MISO) uptake in the bleomycin mouse model of fibrosis 1, we too were surprised not to demonstrate a similar signal in patients with idiopathic pulmonary fibrosis (IPF). However, as acknowledged, there are other examples of positron emission tomography (PET) tracers, such as cis-4- 18 F-fluoro- l -proline, yielding PET signals in animal lung fibrosis models that have not been replicated in humans with fibrotic lung disease 2, 3. In vivo PET imaging in IPF patients shows no significant evidence of lung tissue hypoxia https://bit.ly/3fywY7K
